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The marked increases in protein levels of BNIP3, P62, and PARKIN were clearly observed in the tibialis anterior muscle of mice with castration (112), and the increased ratio of LC3 II/LC3 I in mice with hypogonadism, which indicates a strong association between androgen deficiency and enhancement of mitophagy (113)

doi: 10.1016/j.mce.2011.08.008 8 HaradaNHanadaKMinamiYKitakazeTOgataYTokumotoHet al

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Natalie Rasgon, MD, PhD, professor of psychiatry and behavioral sciences at Stanford, described the findings as "an exciting addition to our understanding of the mechanisms of depressive illness." "As a clinical psychiatrist, I have treated many people with this disorder in my practice," she said